How Metabolon Adds Power and Insights to Your Research

Delivering a Complete Picture

With more than 20 years of experience and continuous innovation, Metabolon has created the industry’s most advanced system for measuring and understanding the metabolome.

Metabolon’s proprietary metabolomics technology delivers the highest level of confidence in the annotation (Level 1) and can detect and identify 5,400+ metabolites within any biological sample. Our sophisticated and precise analysis of the metabolome detects endogenous metabolites and those deriving from the microbiome, lifestyle, or environmental factors (e.g. food, drugs, and chemicals).

Cited in more than 3,500 peer-reviewed publications, our proven technology has enabled thousands of researchers from biopharma, consumer goods, academia, and population health organizations to make novel discoveries—revealing critical insights that have advanced scientific research around the world.

Where Knowledge Comes to Life

Metabolon’s unmatched chemical library and biological interpretation expertise makes it possible to identify, track, and map metabolites across 70 major biochemical pathways.

Incomplete metabolomic coverage creates a fragmented view that may lead to uncertainty, and unreliable conclusions. You can have confidence that Metabolon will deliver the most comprehensive mechanistic view of the underlying biology of your subject with complete, accurate, and reliable interpretation that delivers knowledge, not just data.Metabolon’s Global Discovery Panel provides the industry’s broadest class coverage from a single sample.

• Amino Acid Metabolism
• Cofactor & Vitamin Metabolism
• Nucleotide Metabolism
• Microbiome Metabolism
• Carbohydrate Metabolism
• Energy Metabolism
• Lipid Metabolism
• Exogenous Metabolism

Cast a wide research net with our global metabolomics technology. Identify 5,400+ metabolites across 70 major biochemical pathways.

Validation & Application

Precision Metabolomics™ technology delivers the highest confidence in metabolite identification (Level 1*), allowing for broad applicability.

The Power of Our Technology

Global Discovery Panel

5,400+ metabolites
70 major pathways

Targeted Panels & Single Analyte Assays

1,000 individual lipid species

• Our unique platform provides single point quantitation of 14 lipid classes, including principal phospholipid, sphingolipid, and neutral lipid classes.

450+ metabolites covered by ready-to-use absolute quantification assays

• Fit-For-Purpose Biomarker Validation.
• Capability to adhere to Good Clinical Practice (GCP)/ Good Clinical Laboratory Practice (GCLP) standards.
• Extensive Method Validation according to FDA Bioanalytical Method Validation Guidance, 2018 or EMA Guideline on Bioanalytical Method Validation, 2011.
• Capability to develop/validate methods and perform diagnostic testing on human samples according to regulations certified by Clinical Laboratory Improvement Amendments (CLIA) and accredited by the College of American Pathologists (CAP) for diagnostic testing on human samples.

Our Expertise

200+ patents
3,500+ publications
10,000+ studies

Centered on Quality and Your Success

Metabolon’s proprietary metabolomics technology delivers the highest confidence in metabolite identification (Tier 1*), allowing for broad applicability.

Study Design Consultation

With expertise honed over more than 10,000 projects, our early study design guidance can help ensure your study is properly powered, properly controlled, and properly aligned to your research objectives.

The central elements of good study design are clearly defined objectives, an adequate spectrum of groups, and proper controls.

Our team collaborates with you to design your research questions so that salient “cause and effect” metabolic changes are detected with proper consideration of sample types, time-points, doses, and phenotypic/disease severity.

Sample Collection and Handling

Samples are immediately logged into our customized laboratory information management system (mLIMS™), which supports traceability and assures sample quality and quick turnaround. Samples are stored in carefully monitored, temperature-controlled freezers, backed by generators, until they are ready for processing in our labs.

The Metabolon Study Success Sample Handling Kit is offered at no charge as part of your metabolomics study and provides the tools needed to make the process quick, easy, and worry-free, with best practices developed from over 20 years of best-inclass metabolomics study experience.

Advanced Mass Spec. Data Generation

Metabolon’s Global Discovery Panel detects more unique metabolites than any other platform available today.

Samples are processed using ultra high-performance liquid chromatography/tandem accurate mass spectrometry (UHPLC/MS/MS) methods. This level of precision generates a vast amount of high-quality raw data. All systems are operated according to Standard Operating Procedures (SOPs) in a rigorously controlled environment to remove as much variability from the process as possible.

Our hyper-focus on data quality means that extra samples are reserved for quality control to ensure comparability of your results.

Data Curation and Metabolite Identification

Expansive metabolomics data sets often contain noisy ion features. Our proprietary technology filters and processes data using a chemocentric approach to rapidly and efficiently remove noise and positively identify metabolites.

Our software compares the generated data against our extensive and proven metabolite identification library to identify relevant metabolites with the highest level of confidence in the annotation (Level 1).

Our highly trained curation staff has the skills and technical expertise to confidently navigate large data sets to deliver a clear, reliable, and accurate view of your results.

Data Science and Bioinformatics

Our integrated bioinformatics solution makes it possible to efficiently and accurately mine our vast metabolomics compound library for every study, to ensure consistently reliable results—every time. Each step of our process has been built to deliver the benefit of usable and well-refined data from which insights can be derived.

With over 5,400 compounds in our proprietary reference library, Metabolon has the most comprehensive coverage across over 70 metabolic pathways to inform your study and enable novel discoveries in your research that are simply not possible with other platforms or -omics analysis.

Data Interpretation and Consultative Support

Our team of PhD scientists leverages our proprietary biochemical pathway knowledgebase and powerful bioinformatics to generate meaningful biological insights from complex data sets and narrate a comprehensive story of your research discoveries.

Our experienced biostatistical team provides statistical analysis of your data with univariate significance tests (t-tests, ANOVA, repeated measures analysis).
Study directors are assigned to your study to provide post-project support and live consultation to help answer any questions and inform next steps in your research.

High-Quality Data and Interactive Visualization Tools

Quality, Usable Data

Metabolon’s client data deliverables are a suite of tools that help you review, analyze, and understand your project data. Our full deliverable includes:

• Client Data Table (CDT) tabular data in a consistent format
• Heat maps in a tabular format
• Box plots in PDF format
• Methods and QC document

Our secure deliverable format makes it easy to import study data into
popular analysis and statistical tools, such as R or Python.

MyMetabolon™ Client Portal

The MyMetabolon client portal—hosted securely in the cloud—allows you to access, share, and visualize your metabolomics data. Within you can utilize a multi-functional data display that incorporates heat maps, charts, pathway enrichment data, and an annotated biochemical “Network View”—an interactive visual rendering of the data within the associated metabolic pathways—for each experiment.

Results can also be viewed in the context of the whole metabolome with our curated Pathway Map—an interactive visual rendering of all charted biochemical pathways. This provides a more holistic picture of your metabolomics study results and empowers deeper understanding of biological significance.